Joerg A. Kallen: search on Z-Library

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1

Optimizing a weakly binding fragment into a potent RORγt inverse agonist with efficacy in an in vivo inflammation model

Carcache, David, Vulpetti, Anna, Kallen, Joerg, Mattes, Henri, Orain, David, Stringer, Rowan, Vangrevelinghe, Eric, Wolf, Romain M, Kaupmann, Klemens, Ottl, Johannes, Dawson King, Janet, Cooke, Nigel

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.88 MB

english, 2018

2

ChemInform Abstract: Macrolide Analogues (II) of the Novel Immunosuppressant Sanglifehrin: New Application of the Ring-Closing Metathesis Reaction.

Luisa M. Martin Cabrejas, Stefan Rohrbach, Dieter Wagner, Joerg Kallen, Gerhard Zenke, Juergen Wagner

Journal:

Year:

1999

File:

PDF, 27 KB

1999

3

1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1

Sompong Wattanasin, Joerg Kallen, Stewart Myers, Qin Guo, Michael Sabio, Claus Ehrhardt, Rainer Albert, Ulrich Hommel, Gisbert Weckbecker, Karl Welzenbach, Gabriele Weitz-Schmidt

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 160 KB

english, 2005

4

Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity

Manuel Koller, Kurt Lingenhoehl, Markus Schmutz, Ivan-Toma Vranesic, Joerg Kallen, Yves P. Auberson, David A. Carcache, Henri Mattes, Silvio Ofner, David Orain, Stephan Urwyler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 546 KB

english, 2011

5

Identification of natural ligands of retinoic acid receptor-related orphan receptor α ligand-binding domain expressed in Sf9 cells––a mass spectrometry approach

Francis Bitsch, Reiner Aichholz, Joerg Kallen, Sabine Geisse, Brigitte Fournier, Jean-Marc Schlaeppi

Journal:

Analytical Biochemistry

Year:

2003

Language:

english

File:

PDF, 766 KB

english, 2003

6

Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke

Steven D. Linton, Teresa Aja, Peter R. Allegrini, Thomas L. Deckwerth, Jose-Luis Diaz, Bastian Hengerer, Julia Herrmann, Kathy G. Jahangiri, Joerg Kallen, Donald S. Karanewsky, Steven P. Meduna, Kip N

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 295 KB

english, 2004

7

10.1038/89058

Weitz-Schmidt, Gabriele, Welzenbach, Karl, Brinkmann, Volker, Kamata, Tetsji, Kallen, Joerg, Bruns, Christian, Cottens, Sylvain, Takada, Yoshikazu, Hommel, Ulrich

Journal:

Nature Medicine

Year:

2001

Language:

english

File:

PDF, 262 KB

english, 2001

8

The central valine concept provides an entry in a new class of non peptide inhibitors of the p53–MDM2 interaction

Pascal Furet, Patrick Chène, Alain De Pover, Thérèse Stachyra Valat, Joanna Hergovich Lisztwan, Joerg Kallen, Keiichi Masuya

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

9

X-Ray Structure of the hRORα LBD at 1.63 Å: Structural and Functional Data that Cholesterol or a Cholesterol Derivative Is the Natural Ligand of RORα

Joerg A. Kallen, Jean-Marc Schlaeppi, Francis Bitsch, Sabine Geisse, Martin Geiser, Isabelle Delhon, Brigitte Fournier

Journal:

Year:

2002

Language:

english

File:

PDF, 433 KB

english, 2002

10

Conformational polymorphism of cyclosporin A

Danièle Altschuh, Werner Braun, Joerg Kallen, Vincent Mikol, Claus Spitzfaden, Jean-Claude Thierry, Olivier Vix, Malcolm D Walkinshaw, Kurt Wüthrich

Journal:

Year:

1994

Language:

english

File:

PDF, 1.30 MB

english, 1994

11

Conformational differences of an immunosuppressant peptolide in a single crystal and in a crystal complex with human cyclophilin A

Vincent Mikol, Paul Taylor, Joerg Kallen, Malcolm D. Walkinshaw

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 615 KB

english, 1998

12

X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A

Joerg Kallen, Vincent Mikol, Paul Taylor, Malcolm D.Walkinshaw

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 1.10 MB

english, 1998

13

Crystallisation and preliminary X-ray diffraction studies of cyclophilin-tetrapeptide and cyclophilin-cyclosporin complexes

Mauro Zurini, Joerg Kallen, Vincent Mikol, Gaston Pfluegl, Johan N. Jansonius, Malcolm D. Walkinshaw

Journal:

Year:

1990

Language:

english

File:

PDF, 563 KB

english, 1990

14

Crystallization and preliminary X-ray crystallographic study of interleukin-8

Manfred Auer, Joerg Kallen, Sabine Schleischitz, Malcolm D. Walkinshaw, Erich Wasserbauer, Gerald Ehn, Ivan J.D. Lindley

Journal:

Year:

1990

Language:

english

File:

PDF, 469 KB

english, 1990

15

Cyclosporin A—cyclophilin complex formation A model based on X-ray and NMR data

Claus Spitzfaden, Hans-Peter Weber, Werner Braun, Joerg Kallen, Gerhard Wider, Hans Widmer, Malcolm D. Walkinshaw, Kurt Wüthrich

Journal:

Year:

1992

Language:

english

File:

PDF, 1.15 MB

english, 1992

16

The X-ray structure of a tetrapeptide bound to the active site of human cyclophilin A

Joerg Kallen, Malcolm D. Walkinshaw

Journal:

Year:

1992

Language:

english

File:

PDF, 4.01 MB

english, 1992

17

The X-ray Crystal Structure of the First RNA Recognition Motif and Site-Directed Mutagenesis Suggest a Possible HuR Redox Sensing Mechanism

Roger Marc Benoit, Nicole-Claudia Meisner, Joerg Kallen, Patrick Graff, René Hemmig, Régis Cèbe, Christian Ostermeier, Hans Widmer, Manfred Auer

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 2.17 MB

english, 2010

18

Inhibition of Interleukin-6-Transsignaling via gp130-Fc in Hemorrhagic Shock and Sepsis

Soeren Torge Mees, Sietje Toellner, Kerstin Marx, Fred Faendrich, Karl Josef Kallen, Joerg Schroeder, Joerg Haier, Volker Kahlke

Journal:

Journal of Surgical Research

Year:

2009

Language:

english

File:

PDF, 250 KB

english, 2009

19

Tetra-substituted imidazoles as a new class of inhibitors of the p53–MDM2 interaction

Vaupel, Andrea, Bold, Guido, De Pover, Alain, Stachyra-Valat, Thérèse, Hergovich Lisztwan, Joanna, Kallen, Joerg, Masuya, Keiichi, Furet, Pascal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.55 MB

english, 2014

20

Complexes of aspartate aminotransferase with hydroxylamine derivatives: spectral studies in solution and in the crystalline state

Delbaere, Louis T.J., Kallen, Joerg, Markovic-Housley, Zora, Khomutov, Alex R., Khomutov, Radii M., Karpeisky, Marat Y., Jansonius, Johan N.

Journal:

Year:

1989

Language:

english

File:

PDF, 1.08 MB

english, 1989

21

Estrogen Receptor Modulators: Identification and Structure−Activity Relationships of Potent ERα-Selective Tetrahydroisoquinoline Ligands

Renaud, Johanne, Bischoff, Serge François, Buhl, Thomas, Floersheim, Philipp, Fournier, Brigitte, Halleux, Christine, Kallen, Joerg, Keller, Hansjoerg, Schlaeppi, Jean-Marc, Stark, Wilhelm

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 356 KB

english, 2003

22

Selective Estrogen Receptor Modulators with Conformationally Restricted Side Chains. Synthesis and Structure−Activity Relationship of ERα-Selective Tetrahydroisoquinoline Ligands

Renaud, Johanne, Bischoff, Serge François, Buhl, Thomas, Floersheim, Philipp, Fournier, Brigitte, Geiser, Martin, Halleux, Christine, Kallen, Joerg, Keller, Hansjoerg, Ramage, Paul

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 493 KB

english, 2005

23

X-ray Crystal Structure of 28- O -Methylrapamycin complexed with FKBP12: Is the Cyclohexyl Moiety Part of the Effector Domain of Rapamycin?

Kallen, Joerg A., Sedrani, Richard, Cottens, Sylvain

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 220 KB

english, 1996

24

Corrigendum to “Tetra-substituted imidazoles as a new class of inhibitors of the p53–MDM2 interaction” [Bioorg. Med. Chem. Lett. 24 (9) (2014) 2110–2114]

Vaupel, Andrea, Bold, Guido, De Pover, Alain, Stachyra-Valat, Thérèse, Hergovich Lisztwan, Joanna, Kallen, Joerg, Masuya, Keiichi, Furet, Pascal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

File:

PDF, 176 KB

2015

25

Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53–MDM2 interaction with a distinct binding mode

Gessier, François, Kallen, Joerg, Jacoby, Edgar, Chène, Patrick, Stachyra-Valat, Thérèse, Ruetz, Stephan, Jeay, Sébastien, Holzer, Philipp, Masuya, Keiichi, Furet, Pascal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.64 MB

english, 2015

26

Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors

Holzer, Philipp, Masuya, Keiichi, Furet, Pascal, Kallen, Joerg, Valat-Stachyra, Therese, Ferretti, Stéphane, Berghausen, Joerg, Bouisset-Leonard, Michèle, Buschmann, Nicole, Pissot-Soldermann, Carole,

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.05 MB

english, 2015

27

SELECTIVE INHIBITION OF THE LFA-1/ICAM-1 BINDING BY HMG-COA REDUCTASE INHIBITORS: IDENTIFICATION OF A NOVEL BINDING SITE.

Weitz-Schmidt, Gabriele, Brinkmann, Volker, Cottens, Sylvain, Hommel, Ulrich, Kallen, Joerg, Welzenbach, Karl

Journal:

Transplantation Journal

Year:

2000

File:

PDF, 960 KB

2000

28

Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument

Furet, Pascal, Masuya, Keiichi, Kallen, Joerg, Stachyra-Valat, Thérèse, Ruetz, Stephan, Guagnano, Vito, Holzer, Philipp, Mah, Robert, Stutz, Stefan, Vaupel, Andrea, Chène, Patrick, Jeay, Sébastien, Sc

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 816 KB

english, 2016

29

Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists

Hintermann, Samuel, Guntermann, Christine, Mattes, Henri, Carcache, David A., Wagner, Juergen, Vulpetti, Anna, Billich, Andreas, Dawson, Janet, Kaupmann, Klemens, Kallen, Joerg, Stringer, Rowan, Orain

Journal:

Year:

2016

Language:

english

File:

PDF, 974 KB

english, 2016

30

Structural states of RORγt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds

Kallen, Joerg, Izaac, Aude, Be, Celine, Arista, Luca, Orain, David, Kaupmann, Klemens, Guntermann, Christine, Hoegenauer, Klemens, Hintermann, Samuel

Journal:

Year:

2017

Language:

english

File:

PDF, 2.29 MB

english, 2017

31

Effect of the acylation of TEAD4 on its interaction with co-activators YAP and TAZ

Mesrouze, Yannick, Meyerhofer, Marco, Bokhovchuk, Fedir, Fontana, Patrizia, Zimmermann, Catherine, Martin, Typhaine, Delaunay, Clara, Izaac, Aude, Kallen, Joerg, Schmelzle, Tobias, Erdmann, Dirk, Chèn

Journal:

Protein Science

Year:

2017

Language:

english

File:

PDF, 1.30 MB

english, 2017

32

X-ray structures and feasibility assessment of CLK2 inhibitors for Phelan McDermid syndrome

Lerchner, Andreas Markus, Kallen, Joerg, Bergsdorf, Christian, Arnaud, Bertrand, Bernhard, Mario, Brichet, Murielle, Cobos-Correa, Amanda, Elhajouji, Azeddine, Freuler, Felix, Galimberti, Ivan, Guibou

Journal:

Year:

2018

Language:

english

File:

PDF, 2.30 MB

english, 2018

33

Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface

Mesrouze, Yannick, Bokhovchuk, Fedir, Izaac, Aude, Meyerhofer, Marco, Zimmermann, Catherine, Fontana, Patrizia, Schmelzle, Tobias, Erdmann, Dirk, Furet, Pascal, Kallen, Joerg, Chène, Patrick

Journal:

Protein Science

Year:

2018

Language:

english

File:

PDF, 1.36 MB

english, 2018

34

In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor

Vaupel, Andrea, Holzer, Philipp, Ferretti, Stephane, Guagnano, Vito, Kallen, Joerg, Mah, Robert, Masuya, Keiichi, Ruetz, Stephan, Rynn, Caroline, Schlapbach, Achim, Stachyra, Thérèse, Stutz, Stefan, T

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 1.08 MB

english, 2018

35

Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy

Bokhovchuk, Fedir, Mesrouze, Yannick, Izaac, Aude, Meyerhofer, Marco, Zimmermann, Catherine, Fontana, Patrizia, Schmelzle, Tobias, Erdmann, Dirk, Furet, Pascal, Kallen, Joerg, Chène, Patrick

Journal:

Year:

2019

Language:

english

File:

PDF, 1.29 MB

english, 2019

36

Structural states of Hdm2 and HdmX: X‐ray elucidation of adaptations and binding interactions for different chemical compound classes

Kallen, Joerg, Izaac, Aude, Chau, Suzanne, Wirth, Emmanuelle, Schoepfer, Joseph, Mah, Robert, Schlapbach, Achim, Stutz, Stefan, Vaupel, Andrea, Guagnano, Vito, Masuya, Keiichi, Stachyra, Therese-Marie

Journal:

Year:

2019

Language:

english

File:

PDF, 3.02 MB

english, 2019

37

Structure-based and property-driven optimization of N-aryl imidazoles towards potent and selective oral RORγt inhibitors

Hoegenauer, Klemens, Kallen, Joerg, Jimenez-Nunez, Eloisa, Strang, Ross, Ertl, Peter, Cooke, Nigel G., Hintermann, Samuel, Voegtle, Markus, Betschart, Claudia, Mckay, Daniel J. J., Wagner, Juergen, Ot

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 967 KB

english, 2019

38

Structure-based and property-driven optimization of N-aryl imidazoles towards potent and selective oral RORγt inhibitors

Hoegenauer, Klemens, Kallen, Joerg, Jimenez-Nunez, Eloisa, Strang, Ross, Ertl, Peter, Cooke, Nigel G., Hintermann, Samuel, Voegtle, Markus, Betschart, Claudia, Mckay, Daniel J. J., Wagner, Juergen, Ot

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 967 KB

2019